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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BROX All Species: 37.27
Human Site: T226 Identified Species: 74.55
UniProt: Q5VW32 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5VW32 NP_653296.2 411 46476 T226 F Y Q K A D H T L S S L E P A
Chimpanzee Pan troglodytes XP_001173118 411 46488 T226 F Y Q K A D H T L S S L E P A
Rhesus Macaque Macaca mulatta XP_001099998 411 46403 T226 F Y Q K A D H T L S S L E P A
Dog Lupus familis XP_536151 461 51635 T276 F Y Q K A D H T L S S L E P A
Cat Felis silvestris
Mouse Mus musculus Q8K2Q7 411 46183 T226 F Y Q K A D H T L S S L E P A
Rat Rattus norvegicus Q4V8K5 411 46173 T226 F Y Q K A D H T L S S L E P A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512145 469 53140 T284 F Y Q R A D H T L S S L E P M
Chicken Gallus gallus XP_419397 411 46534 T226 F Y Q K A D Q T L S S L D P T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio A3KQV2 411 46106 T226 F Y Q K A D H T L N T L D P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120754 420 47151 T235 L F L D A A N T L R S F K S E
Nematode Worm Caenorhab. elegans Q22885 427 48281 C236 I F S K A D Q C L N N L P D E
Sea Urchin Strong. purpuratus XP_784283 330 36694 G152 K C L R S A A G I F N Y I D E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 99.2 84.8 N.A. 91.7 92.4 N.A. 78.4 86.3 N.A. 74.2 N.A. N.A. 45 39.5 34.7
Protein Similarity: 100 99.7 99.5 87.1 N.A. 96.8 96.8 N.A. 82.7 92.9 N.A. 86.3 N.A. N.A. 60 60.8 50.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 86.6 80 N.A. 73.3 N.A. N.A. 26.6 33.3 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 86.6 N.A. 93.3 N.A. N.A. 46.6 53.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 92 17 9 0 0 0 0 0 0 0 50 % A
% Cys: 0 9 0 0 0 0 0 9 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 84 0 0 0 0 0 0 17 17 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 59 0 34 % E
% Phe: 75 17 0 0 0 0 0 0 0 9 0 9 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 67 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 0 9 0 0 0 9 0 0 % I
% Lys: 9 0 0 75 0 0 0 0 0 0 0 0 9 0 0 % K
% Leu: 9 0 17 0 0 0 0 0 92 0 0 84 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 0 0 9 0 0 17 17 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 9 75 0 % P
% Gln: 0 0 75 0 0 0 17 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 17 0 0 0 0 0 9 0 0 0 0 0 % R
% Ser: 0 0 9 0 9 0 0 0 0 67 75 0 0 9 0 % S
% Thr: 0 0 0 0 0 0 0 84 0 0 9 0 0 0 9 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 75 0 0 0 0 0 0 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _